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PEX7 Antibody (aa204-253)

Rabbit Polyclonal Antibody

     
  • WB - PEX7 Antibody (aa204-253) ALS15511
    Western blot of extracts from NIH-3T3 cells, using PEX7 Antibody.
    detail
  • IHC - PEX7 Antibody (aa204-253) ALS15511
    Anti-PEX7 antibody IHC of human breast.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O00628
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 5191
Other Names Peroxisomal targeting signal 2 receptor, PTS2 receptor, Peroxin-7, PEX7, PTS2R
Target/Specificity PEX7 Antibody detects endogenous levels of total PEX7 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsPEX7 Antibody (aa204-253) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEX7 {ECO:0000303|PubMed:9090383, ECO:0000312|HGNC:HGNC:8860}
Function Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed:9090381, PubMed:11931631, PubMed:22057399, PubMed:25538232). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed:11931631, PubMed:22057399, PubMed:25538232). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed:11546814, PubMed:25538232).
Cellular Location Cytoplasm, cytosol. Peroxisome matrix. Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5
Tissue Location Ubiquitous (PubMed:9090381). Highest expression in pancreas, skeletal muscle and heart (PubMed:9090381)
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

References

Purdue P.E.,et al.Nat. Genet. 15:381-384(1997).
Braverman N.,et al.Nat. Genet. 15:369-376(1997).
Braverman N.,et al.Genomics 63:181-192(2000).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS15511
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