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RAB3GAP1 Antibody (aa538-587)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q15042 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 111kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 22930 |
|---|---|
| Other Names | Rab3 GTPase-activating protein catalytic subunit, RAB3 GTPase-activating protein 130 kDa subunit, Rab3-GAP p130, Rab3-GAP, RAB3GAP1, KIAA0066, RAB3GAP |
| Target/Specificity | RAB3GAP1 Antibody detects endogenous levels of total RAB3GAP1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | RAB3GAP1 Antibody (aa538-587) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB3GAP1 |
|---|---|
| Synonyms | KIAA0066, RAB3GAP |
| Function | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9030515, PubMed:10859313, PubMed:24891604). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). |
| Cellular Location | Cytoplasm. Endoplasmic reticulum. Note=In neurons, it is enriched in the synaptic soluble fraction. |
| Tissue Location | Ubiquitous.. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
References
Nomura N.,et al.DNA Res. 1:223-229(1994).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Fukui K.,et al.J. Biol. Chem. 272:4655-4658(1997).
Oishi H.,et al.J. Biol. Chem. 273:34580-34585(1998).
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