|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IHC-P (1:50-1:100),|
|Other Names||SHC-transforming protein 3, Neuronal Shc, N-Shc, Protein Rai, SHC-transforming protein C, Src homology 2 domain-containing-transforming protein C3, SH2 domain protein C3, SHC3, NSHC, SHCC|
|Target/Specificity||SHC3 Antibody detects endogenous levels of total SHC3 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||SHC3 / SHCC Antibody (aa291-340) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.|
|Tissue Location||Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Nakamura T.,et al.Oncogene 13:1111-1121(1996).
Pelicci G.,et al.Oncogene 13:633-641(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Liu H.Y.,et al.J. Biol. Chem. 277:26046-26056(2002).
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