|Application ||IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml),|
|Other Names||Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2, Protein WAVE-2, Verprolin homology domain-containing protein 2, WASF2, WAVE2|
|Target/Specificity||WASF4 Antibody detects endogenous levels of total WASF4 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||SCAR2 / WAVE2 Antibody (aa190-239) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane|
|Tissue Location||Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Suetsugu S.,et al.Biochem. Biophys. Res. Commun. 260:296-302(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Miki H.,et al.Nature 408:732-735(2000).
Gautreau A.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004).
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