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>   home   >   Products   >   Primary Antibodies   >   JHDM1A / KDM2A Antibody (Internal)   

JHDM1A / KDM2A Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - JHDM1A / KDM2A Antibody (Internal) ALS15555
    KDM2A antibody (0.5 ug/ml) staining of Human Uterus lysate (35 ug protein/ml in RIPA buffer).
  • IHC - JHDM1A / KDM2A Antibody (Internal) ALS15555
    Anti-JHDM1A / KDM2A antibody IHC staining of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y2K7
Reactivity Human, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 133kDa
Dilution ELISA (1:32000), IHC-P (5 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 22992
Other Names Lysine-specific demethylase 2A, 1.14.11.27, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
Target/Specificity Human KDM2A / FBXL11.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsJHDM1A / KDM2A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM2A
Synonyms CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
Function Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Cellular Location Nucleus, nucleoplasm Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2
Tissue Location Widely expressed, with highest levels in brain, testis and ovary, followed by lung
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

References

Ilyin G.P.,et al.Genomics 67:40-47(2000).
Tsuneoka M.,et al.Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
Iuchi S.,et al.Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:63-70(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).

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$ 395.00
Cat# ALS15555
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