NPR3 Antibody (aa520-533)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P17342 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 60kDa |
Dilution | ELISA (1:16000), IHC-P (10 µg/ml), WB (1-3 µg/ml) |
Gene ID | 4883 |
---|---|
Other Names | Atrial natriuretic peptide receptor 3, Atrial natriuretic peptide clearance receptor, Atrial natriuretic peptide receptor type C, ANP-C, ANPR-C, NPR-C, NPR3, ANPRC, C5orf23, NPRC |
Target/Specificity | Human NPR3. The immunizing peptide represents the cytoplasmic part of the protein. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | NPR3 Antibody (aa520-533) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NPR3 |
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Synonyms | ANPRC, C5orf23, NPRC |
Function | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
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Background
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
References
Lowe D.G.,et al.Nucleic Acids Res. 18:3412-3412(1990).
Porter J.G.,et al.Biochem. Biophys. Res. Commun. 171:796-803(1990).
Rae J.L.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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