|Application ||IHC-P, IHC-Fr|
|Dilution||IHC-Fr (1:100-1:400), IHC-P (1:50),|
|Other Names||Pro-thyrotropin-releasing hormone, Pro-TRH, Prothyroliberin, Thyrotropin-releasing hormone, TRH, Protirelin, TSH-releasing factor, Thyroliberin, Thyrotropin-releasing factor, TRF, TRH|
|Target/Specificity||The antiserum reacts with TRH containing cell bodies in the hypothalamus present through out the hypothalamic gray matter.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TRH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.|
|Tissue Location||Hypothalamus. Expressed in the hair follicle epithelium (at protein level).|
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Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.
Yamada M.,et al.Mol. Endocrinol. 4:551-556(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gaspar E.,et al.FASEB J. 24:393-403(2010).
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