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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CPNE6 / N-COPINE Antibody (clone 6.4_1B4)   

CPNE6 / N-COPINE Antibody (clone 6.4_1B4)

Mouse Monoclonal Antibody

     
  • IHC - CPNE6 / N-COPINE Antibody (clone 6.4_1B4) ALS15565
    Anti-CPNE6 / N-COPINE antibody IHC staining of human skeletal muscle.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP
Primary Accession O95741
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6.4_1B4
Calculated MW 62kDa
Dilution ICC (10 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 9362
Other Names Copine-6, Copine VI, Neuronal-copine, N-copine, CPNE6
Target/Specificity Human CPNE6 / N-COPINE
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCPNE6 / N-COPINE Antibody (clone 6.4_1B4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPNE6 (HGNC:2319)
Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin- coated membrane vesicles in a calcium-dependent manner {ECO:0000250|UniProtKB:Q9Z140}
Tissue Location Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).
Research Areas
Citations (0)

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Background

May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. May have a role in synaptic plasticity (By similarity).

References

Nakayama T.,et al.FEBS Lett. 428:80-84(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15565
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