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>   home   >   Products   >   Primary Antibodies   >   HNRNPC / HNRNP C Antibody (clone 55.1_3A9)   

HNRNPC / HNRNP C Antibody (clone 55.1_3A9)

Mouse Monoclonal Antibody

     
  • IHC - HNRNPC / HNRNP C Antibody (clone 55.1_3A9) ALS15566
    Anti-HNRNPC / HNRNP C antibody IHC staining of human skin, epidermis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP
Primary Accession P07910
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 55.1_3A9
Calculated MW 34kDa
Dilution ICC (10 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 3183
Other Names Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC, HNRPC
Target/Specificity Human HNRNPC
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsHNRNPC / HNRNP C Antibody (clone 55.1_3A9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPC
Synonyms HNRPC
Function Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
Cellular Location Nucleus. Note=Component of ribonucleosomes.
Volume 250 µl
Citations (0)

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Background

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

References

Burd C.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9788-9792(1989).
Swanson M.S.,et al.Mol. Cell. Biol. 7:1731-1739(1987).
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15566
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