|Application ||WB, IHC-P, IF, ICC, E|
|Dilution||ELISA (1:10000), ICC (1:200-1:1000), IF (1:1000), IHC-P (1:50), WB (1:500-1:2000)|
|Other Names||Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||ZBTB16 / PLZF Antibody (clone 5B3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Tissue Location||Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung|
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Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Chen Z.,et al.EMBO J. 12:1161-1167(1993).
Zhang T.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999).
Chen S.-J.,et al.J. Clin. Invest. 91:2260-2267(1993).
Hoatlin M.E.,et al.Blood 94:3737-3747(1999).
Itoh T.,et al.Science 291:1047-1051(2001).
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