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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PNPLA2 / ATGL Antibody   

PNPLA2 / ATGL Antibody

Rabbit Polyclonal Antibody

     
  • IHC - PNPLA2 / ATGL Antibody ALS15577
    Anti-PNPLA2 / ATGL antibody IHC staining of human heart.
  • WB - PNPLA2 / ATGL Antibody ALS15577
    Western blot of PNPLA2 / ATGL antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q96AD5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution IHC-P (5 µg/ml), WB (0.5-4 µg/ml),
Additional Information
Gene ID 57104
Other Names Patatin-like phospholipase domain-containing protein 2, 3.1.1.3, Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, IPLA2-zeta, Pigment epithelium-derived factor, TTS2.2, Transport-secretion protein 2, TTS2, PNPLA2, ATGL
Target/Specificity The antibody recognizes 54 kD ATGL in samples from human and mouse origins. Reactivity to other species has not been tested.
Reconstitution & Storage Short term +4°C (no longer than one week); Long term -20°C; Aliquot to avoid freeze/thaw cycles.
PrecautionsPNPLA2 / ATGL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PNPLA2
Synonyms ATGL
Function Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Cellular Location Lipid droplet. Cell membrane; Single-pass type II membrane protein
Tissue Location Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level)
Research Areas
Citations (0)

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Background

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

References

Zimmermann R.,et al.Science 306:1383-1386(2004).
Strahl T.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Jenkins C.M.,et al.J. Biol. Chem. 279:48968-48975(2004).

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$ 395.00
Cat# ALS15577
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