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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PRC1 Antibody (Internal)   

PRC1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - PRC1 Antibody (Internal) ALS15618
    Anti-PRC1 antibody IHC staining of human skin.
  • IF - PRC1 Antibody (Internal) ALS15618
    Immunofluorescence of PRC1 in mouse skeletal muscle tissue with PRC1 antibody at 20 ug/ml.
  • WB - PRC1 Antibody (Internal) ALS15618
    Western blot analysis of PRC1 in human skeletal muscle tissue lysate with Prc1 antibody at (A)...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession O43663
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 72kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 9055
Other Names Protein regulator of cytokinesis 1, PRC1 {ECO:0000312|EMBL:AAC02688.1}
Target/Specificity Human PRC1. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsPRC1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRC1 (HGNC:9341)
Function Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis
Tissue Location Overexpressed in bladder cancer cells (PubMed:17409436).
Research Areas
Citations (0)

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Background

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle.

References

Jiang W.,et al.Mol. Cell 2:877-885(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mollinari C.,et al.J. Cell Biol. 157:1175-1186(2002).

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$ 395.00
Cat# ALS15618
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