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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CLEC7A / Dectin 1 Antibody (Internal)   

CLEC7A / Dectin 1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - CLEC7A / Dectin 1 Antibody (Internal) ALS15621
    Anti-CLEC7A / Dectin 1 antibody IHC staining of human testis.
  • IF - CLEC7A / Dectin 1 Antibody (Internal) ALS15621
    Immunofluorescence of CLEC7A in human spleen tissue withCLEC7A antibody at 20 ug/ml.
  • WB - CLEC7A / Dectin 1 Antibody (Internal) ALS15621
    Western blot analysis of CLEC7A in rat spleen tissue lysate with CLEC7A antibody at (A) 1 and...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9BXN2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Dilution IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 64581
Other Names C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Dectin-1, CLEC7A, BGR, CLECSF12, DECTIN1
Target/Specificity Human CLEC7A / Dectin 1. Multiple isoforms of CLEC7A are known to exist. Immunogenic peptide is conserved among isoforms 1, 3, and 4 (Q9BXN2).
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsCLEC7A / Dectin 1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC7A
Synonyms BGR, CLECSF12, DECTIN1
Function Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).
Cellular Location Cell membrane; Single- pass type II membrane protein Isoform 6: Cytoplasm.
Tissue Location Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Research Areas
Citations (0)

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Background

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).

References

Sobanov Y.,et al.Eur. J. Immunol. 31:3493-3503(2001).
Yokota K.,et al.Gene 272:51-60(2001).
Hermanz-Falcon P.,et al.Immunogenetics 53:288-295(2001).
Willment J.A.,et al.J. Biol. Chem. 276:43818-43823(2001).
Gruenebach F.,et al.Exp. Hematol. 30:1309-1315(2002).

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$ 395.00
Cat# ALS15621
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