ZFYVE21 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | Q9BQ24 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 27kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 79038 |
---|---|
Other Names | Zinc finger FYVE domain-containing protein 21, ZF21, ZFYVE21 |
Target/Specificity | Human ZFYVE21. At least two isoforms of ZF21 are known to exist; this antibody will detect both isoforms. |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | ZFYVE21 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZFYVE21 |
---|---|
Function | Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta- 1/ITGB1 cell surface expression. |
Cellular Location | Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker |
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Background
Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.
References
Zheng H.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Nagano M.,et al.J. Biol. Chem. 285:21013-21022(2010).
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