|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Cysteine-rich motor neuron 1 protein, CRIM-1, Cysteine-rich repeat-containing protein S52, Processed cysteine-rich motor neuron 1 protein, CRIM1, S52|
|Target/Specificity||Human CRIM1. CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||CRIM1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.|
|Cellular Location||Processed cysteine-rich motor neuron 1 protein: Secreted|
|Tissue Location||Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level)|
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May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
Kolle G.V.,et al.Mech. Dev. 90:181-193(2000).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Wilkinson L.,et al.J. Biol. Chem. 278:34181-34188(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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