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Angiogenin / ANG Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - Angiogenin / ANG Antibody (Internal) ALS15646
    Anti-Angiogenin / ANG antibody IHC staining of human kidney.
    detail
  • IF - Angiogenin / ANG Antibody (Internal) ALS15646
    Immunofluorescence of ANG in human liver tissue with ANG antibody at 20 ug/ml.
    detail
  • WB - Angiogenin / ANG Antibody (Internal) ALS15646
    Western blot analysis of ANG in rat liver tissue lysate with Ang antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P03950
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 283
Other Names Angiogenin, 3.1.27.-, Ribonuclease 5, RNase 5, ANG, RNASE5
Target/Specificity Human ANG. Two alternatively spliced transcript variants have been observed.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAngiogenin / ANG Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANG
Synonyms RNASE5
Function Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (PubMed:1400510, PubMed:21855800). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (PubMed:8127865). Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (PubMed:12051708). Angiogenin induces vascularization of normal and malignant tissues (PubMed:19354288). Angiogenic activity is regulated by interaction with RNH1 in vivo (PubMed:19354288).
Cellular Location Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708)
Tissue Location Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons
Research Areas
Citations (0)
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Background

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

References

Kurachi K.,et al.Biochemistry 24:5494-5499(1985).
Zhang J.,et al.Mol. Biol. Evol. 19:438-445(2002).
Li J.,et al.Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Wakamatsu A.,et al.Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS15646
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