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SCUBE3 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - SCUBE3 Antibody (Internal) ALS15650
    Anti-SCUBE3 antibody IHC staining of human pancreas.
  • IF - SCUBE3 Antibody (Internal) ALS15650
    Immunofluorescence of SCUBE3 in human kidney tissue with SCUBE3 antibody at 20 ug/ml.
  • WB - SCUBE3 Antibody (Internal) ALS15650
    Western blot analysis of SCUBE3 in mouse kidney tissue lysate with SCUBE3 antibody at (A) 1 and...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q8IX30
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 109kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 222663
Other Names Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)
Target/Specificity Human SCUBE3. At least two isoforms of SCUBE3 are known to exist. SCUBE3 antibody is predicted to not cross-react with other SCUBE members.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSCUBE3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCUBE3 (HGNC:13655)
Function Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Cellular Location Secreted. Cell surface
Tissue Location Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
Research Areas
Citations (0)

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Background

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.

References

Wu B.-T.,et al.J. Biol. Chem. 279:37485-37490(2004).
Pfarr N.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15650
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