SHQ1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | Q6PI26 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 65kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 55164 |
---|---|
Other Names | Protein SHQ1 homolog, SHQ1 |
Target/Specificity | Human SHQ1. Multiple isoforms are known to exist. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | SHQ1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SHQ1 |
---|---|
Function | Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. |
Cellular Location | Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Grozdanov P.N.,et al.RNA 15:1188-1197(2009).
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