SGSM2 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | O43147 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 113kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 9905 |
---|---|
Other Names | Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1, SGSM2, KIAA0397, RUTBC1 |
Target/Specificity | Human SGSM2. Multiple isoforms of SGSM2 are known to exist. SGSM2 antibody is predicted to not cross react with other SGSM family proteins. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | SGSM2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SGSM2 |
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Synonyms | KIAA0397, RUTBC1 |
Function | Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). |
Cellular Location | Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A. |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
References
Yang H.,et al.Genomics 90:249-260(2007).
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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