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>   home   >   Products   >   Primary Antibodies   >   KEAP1 Antibody (C-Terminus)   

KEAP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - KEAP1 Antibody (C-Terminus) ALS15665
    Anti-KEAP1 antibody IHC staining of human prostate.
  • IF - KEAP1 Antibody (C-Terminus) ALS15665
    Immunofluorescence of KEAP1 in human lung tissue with KEAP1 antibody at 20 ug/ml.
  • WB - KEAP1 Antibody (C-Terminus) ALS15665
    Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 antibody at (A) 1 and (B)...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q14145
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Dilution IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 9817
Other Names Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, INrf2, Kelch-like protein 19, KEAP1, INRF2, KIAA0132, KLHL19
Target/Specificity Human KEAP1. At least two isoforms of KEAP1 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsKEAP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KEAP1
Synonyms INRF2, KIAA0132, KLHL19
Function Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus
Tissue Location Broadly expressed, with highest levels in skeletal muscle.
Citations (0)

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Background

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

References

Dhakshinamoorthy S.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 2:167-174(1995).
Ohara O.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 395.00
Cat# ALS15665
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