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>   home   >   Products   >   Primary Antibodies   >   DCP2 Antibody (C-Terminus)   

DCP2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - DCP2 Antibody (C-Terminus) ALS15666
    Anti-DCP2 antibody IHC staining of human small intestine.
  • IF - DCP2 Antibody (C-Terminus) ALS15666
    Immunofluorescence of DCP2 in human testis tissue with DCP2 antibody at 20 ug/ml.
  • WB - DCP2 Antibody (C-Terminus) ALS15666
    Western blot analysis of DCP2 in 293 cell lysate with DCP2 antibody at 1 ug/ml in (A) the...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q8IU60
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 167227
Other Names m7GpppN-mRNA hydrolase, 3.6.1.62, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20, mRNA-decapping enzyme 2, hDpc, DCP2, NUDT20
Target/Specificity Human DCP2. Multiple isoforms of DCP2 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsDCP2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCP2
Synonyms NUDT20
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).
Cellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322).
Tissue Location Expressed in brain and testis. Not detected in heart (at protein level).
Citations (0)

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Background

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

References

Lykke-Andersen J.,et al.Mol. Cell. Biol. 22:8114-8121(2002).
Wang Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12663-12668(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
van Dijk E.,et al.EMBO J. 21:6915-6924(2002).

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$ 395.00
Cat# ALS15666
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