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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   LNPEP Antibody (C-Terminus)   

LNPEP Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - LNPEP Antibody (C-Terminus) ALS15667
    Anti-LNPEP antibody IHC staining of human kidney.
  • IF - LNPEP Antibody (C-Terminus) ALS15667
    Immunofluorescence of LNPEP in human lung tissue with LNPEP antibody at 20 ug/ml.
  • WB - LNPEP Antibody (C-Terminus) ALS15667
    Western blot analysis of LNPEP in human lung tissue lysate with LNPEP antibody at 1 ug/ml in (A)...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9UIQ6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 117kDa
Dilution IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 4012
Other Names Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, 3.4.11.3, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Leucyl-cystinyl aminopeptidase, pregnancy serum form, LNPEP, OTASE
Target/Specificity Human LNPEP. At least three isoforms are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, LNPEP often migrates at 165kD in SDS-PAGE.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLNPEP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LNPEP
Synonyms OTASE
Function Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases
Tissue Location Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon
Research Areas
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Background

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

References

Rogi T.,et al.J. Biol. Chem. 271:56-61(1996).
Laustsen P.G.,et al.Biochim. Biophys. Acta 1352:1-7(1997).
Rasmussen T.E.,et al.Eur. J. Biochem. 267:2297-2306(2000).
Matsumoto H.,et al.Eur. J. Biochem. 268:3259-3266(2001).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15667
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