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>   home   >   Products   >   Primary Antibodies   >   CMPK2 Antibody (C-Terminus)   

CMPK2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CMPK2 Antibody (C-Terminus) ALS15669
    Anti-CMPK2 antibody IHC staining of human adrenal.
  • IF - CMPK2 Antibody (C-Terminus) ALS15669
    Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 ug/ml.
  • WB - CMPK2 Antibody (C-Terminus) ALS15669
    Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 ug/ml
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q5EBM0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 129607
Other Names UMP-CMP kinase 2, mitochondrial, 2.7.4.14, Nucleoside-diphosphate kinase, 2.7.4.6, CMPK2
Target/Specificity Human CMPK2. Multiple isoforms of CMPK2 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCMPK2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CMPK2
Function May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.
Cellular Location Mitochondrion.
Tissue Location Among all investigated tumors, leukemia cells show the most abundant expression.
Citations (0)

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Background

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

References

Xu Y.,et al.J. Biol. Chem. 283:1563-1571(2008).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Amiri M.,et al.Int. J. Biochem. Cell Biol. 45:925-931(2013).

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$ 395.00
Cat# ALS15669
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