|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Long-chain-fatty-acid--CoA ligase 1, 220.127.116.11, Acyl-CoA synthetase 1, ACS1, Long-chain acyl-CoA synthetase 1, LACS 1, Long-chain acyl-CoA synthetase 2, LACS 2, Long-chain fatty acid-CoA ligase 2, Palmitoyl-CoA ligase 1, Palmitoyl-CoA ligase 2, ACSL1, FACL1, FACL2, LACS, LACS1, LACS2|
|Target/Specificity||Human ACSL1. At least three isoforms of ACSL1 are known to exist; this antibody will detect all three isoforms.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FACL2 / ACSL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FACL1, FACL2, LACS, LACS1, LACS2|
|Function||Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.|
|Cellular Location||Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein|
|Tissue Location||Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Abe T.,et al.J. Biochem. 111:123-128(1992).
Ghosh B.,et al.Mol. Cell. Biochem. 151:77-81(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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