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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLCL1 Antibody   

PLCL1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - PLCL1 Antibody ALS15690
    Anti-PLCL1 antibody IHC staining of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q15111
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 123kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 5334
Other Names Inactive phospholipase C-like protein 1, PLC-L1, Phospholipase C-deleted in lung carcinoma, Phospholipase C-related but catalytically inactive protein, PRIP, PLCL1
Target/Specificity Human PLCL1
Reconstitution & Storage Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsPLCL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCL1
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Cellular Location Cytoplasm.
Tissue Location Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma Isoform 1 is predominantly expressed in brain
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.

References

Kohno T.,et al.Hum. Mol. Genet. 4:667-674(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Yoshimura K.,et al.J. Biol. Chem. 276:17908-17913(2001).
Kanematsu T.,et al.EMBO J. 21:1004-1011(2002).

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$ 395.00
Cat# ALS15690
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