PLCL1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q15111 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 123kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 5334 |
---|---|
Other Names | Inactive phospholipase C-like protein 1, PLC-L1, Phospholipase C-deleted in lung carcinoma, Phospholipase C-related but catalytically inactive protein, PRIP, PLCL1 |
Target/Specificity | Human PLCL1 |
Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
Precautions | PLCL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLCL1 |
---|---|
Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. |
Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
References
Kohno T.,et al.Hum. Mol. Genet. 4:667-674(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Yoshimura K.,et al.J. Biol. Chem. 276:17908-17913(2001).
Kanematsu T.,et al.EMBO J. 21:1004-1011(2002).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.