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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   NOD1 Antibody   

NOD1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - NOD1 Antibody ALS15702
    Anti-NOD1 antibody IHC staining of human spleen.
  • IF - NOD1 Antibody ALS15702
    Immunofluorescence of paraformaldehyde-fixed HeLa, using NOD1 antibody at 1:200 dilution.
  • WB - NOD1 Antibody ALS15702
    Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. NOD1 antibody diluted at 1:1000.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9Y239
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 108kDa
Dilution IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 10392
Other Names Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, NOD1, CARD4
Target/Specificity Human NOD1. Predicted cross-reactivity based on amino acid sequence homology: mouse (81%), rat (82%), pig (87%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsNOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOD1
Synonyms CARD4
Function Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
Cellular Location Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells
Tissue Location Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon
Volume 50 µl
Research Areas
Citations (0)

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Background

Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

References

Bertin J.,et al.J. Biol. Chem. 274:12955-12958(1999).
Inohara N.,et al.J. Biol. Chem. 274:14560-14567(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Inohara N.,et al.J. Biol. Chem. 276:2551-2554(2001).

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$ 395.00
Cat# ALS15702
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