|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:3000),|
|Other Names||Lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein, LITAF, PIG7, SIMPLE|
|Target/Specificity||Human LITAF. Predicted cross-reactivity based on amino acid sequence homology: mouse (85%), rat (86%), bovine (86%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||LITAF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression.|
|Cellular Location||Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with membranes of lysosomes|
|Tissue Location||Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression.
Polyak K.,et al.Nature 389:300-306(1997).
Myokai F.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4518-4523(1999).
Moriwaki Y.,et al.J. Biol. Chem. 276:23065-23076(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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