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WWOX Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q9NZC7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Dilution | IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000) |
| Gene ID | 51741 |
|---|---|
| Other Names | WW domain-containing oxidoreductase, 1.1.1.-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1 |
| Target/Specificity | Human WWOX. Predicted cross-reactivity based on amino acid sequence homology: mouse (95%), rat (96%), bovine (93%). |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | WWOX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WWOX |
|---|---|
| Synonyms | FOR, SDR41C1, WOX1 |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Cellular Location | Cytoplasm. Nucleus Mitochondrion. Golgi apparatus. Lysosome Note=Partially localizes to the mitochondria (PubMed:14695174) Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus Localized to the lysosome probably upon binding to VOPP1 (PubMed:30285739). {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:30285739} |
| Tissue Location | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
References
Bednarek A.K.,et al.Cancer Res. 60:2140-2145(2000).
Ried K.,et al.Hum. Mol. Genet. 9:1651-1663(2000).
Bednarek A.K.,et al.Cancer Res. 61:8068-8073(2001).
Paige A.J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:11417-11422(2001).
Chang N.-S.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
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