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WWOX Antibody

Rabbit Polyclonal Antibody

     
  • IF - WWOX Antibody ALS15709
    Immunofluorescence of paraformaldehyde-fixed A549, using WWOX antibody at 1:200 dilution.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9NZC7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 51741
Other Names WW domain-containing oxidoreductase, 1.1.1.-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1
Target/Specificity Human WWOX. Predicted cross-reactivity based on amino acid sequence homology: mouse (95%), rat (96%), bovine (93%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsWWOX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WWOX
Synonyms FOR, SDR41C1, WOX1
Function Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Cellular Location Cytoplasm. Nucleus Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691}
Tissue Location Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines Isoform 5 and isoform 6 may only be expressed in tumor cell lines
Volume 50 µl
Research Areas
Citations (0)

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Background

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

References

Bednarek A.K.,et al.Cancer Res. 60:2140-2145(2000).
Ried K.,et al.Hum. Mol. Genet. 9:1651-1663(2000).
Bednarek A.K.,et al.Cancer Res. 61:8068-8073(2001).
Paige A.J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:11417-11422(2001).
Chang N.-S.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15709
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