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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NR3C1/Glucocorticoid Receptor Antibody (clone 6E6)   

NR3C1/Glucocorticoid Receptor Antibody (clone 6E6)

Mouse Monoclonal Antibody

     
  • IHC - NR3C1/Glucocorticoid Receptor Antibody (clone 6E6) ALS15713
    Anti-NR3C1/Glucocorticoid Receptor antibody IHC staining of human brain, cortex.
  • IF - NR3C1/Glucocorticoid Receptor Antibody (clone 6E6) ALS15713
    Immunofluorescence of PC-2 cells using NR3C1 mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E, Flo
Primary Accession P04150
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6E6
Calculated MW 86kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IF (1:1000), IHC-P (1:200), WB (1:500-1:2000),
Additional Information
Gene ID 2908
Other Names Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Target/Specificity Human GR / Glucocorticoid Receptor
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsNR3C1/Glucocorticoid Receptor Antibody (clone 6E6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR3C1
Synonyms GRL
Function Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
Cellular Location Isoform Alpha: Cytoplasm. Nucleus Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus Isoform Alpha-B: Nucleus. Cytoplasm. Note=After ligand activation, translocates from the cytoplasm to the nucleus
Tissue Location Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803). Isoform Beta: Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes (PubMed:7769088, PubMed:8621628). Isoform Alpha-2: Expressed at low level.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

References

Hollenberg S.M.,et al.Nature 318:635-641(1985).
Encio I.J.,et al.J. Biol. Chem. 266:7182-7188(1991).
Wang W.,et al.Nucleic Acids Res. 39:44-58(2011).
Turner J.D.,et al.Ann. N. Y. Acad. Sci. 1095:334-341(2007).
Munroe D.G.,et al.Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15713
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