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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   DCX / Doublecortin Antibody (clone 2G5)   

DCX / Doublecortin Antibody (clone 2G5)

Mouse Monoclonal Antibody

     
  • IHC - DCX / Doublecortin Antibody (clone 2G5) ALS15721
    Anti-DCX / Doublecortin antibody IHC staining of human brain, cortex.
  • IF - DCX / Doublecortin Antibody (clone 2G5) ALS15721
    Immunofluorescence of HepG2 cells using DCX mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E, Flo
Primary Accession O43602
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2G5
Calculated MW 49kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IF (1:1000), IHC-P (1:200), WB (1:500-1:2000),
Additional Information
Gene ID 1641
Other Names Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Target/Specificity Human DCX / Doublecortin
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsDCX / Doublecortin Antibody (clone 2G5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCX
Synonyms DBCN, LISX
Function Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Cellular Location Cytoplasm. Cell projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips {ECO:0000250|UniProtKB:Q9ESI7}
Tissue Location Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas
Research Areas
Citations (0)

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Background

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

References

Des Portes V.,et al.Cell 92:51-61(1998).
Gleeson J.G.,et al.Cell 92:63-72(1998).
Sossey-Alaoui K.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15721
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