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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PIK3R1 / p85 Alpha Antibody (clone 6G10)   

PIK3R1 / p85 Alpha Antibody (clone 6G10)

Mouse Monoclonal Antibody

     
  • IHC - PIK3R1 / p85 Alpha Antibody (clone 6G10) ALS15722
    Anti-PIK3R1 / p85 Alpha antibody IHC staining of human pancreas.
  • IF - PIK3R1 / p85 Alpha Antibody (clone 6G10) ALS15722
    Immunofluorescence of HeLa cells using PIK3R1 mouse monoclonal antibody (green).
  • IF - PIK3R1 / p85 Alpha Antibody (clone 6G10) ALS15722
    Immunofluorescence of HepG2 cells using PIK3R1 mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E, Flo
Primary Accession P27986
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6G10
Calculated MW 84kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), ICC (1:100), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 5295
Other Names Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1, GRB1
Target/Specificity Human PIK3R1 / p85 Alpha
Reconstitution & Storage For long term storage -20°C is recommended.
PrecautionsPIK3R1 / p85 Alpha Antibody (clone 6G10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3R1
Synonyms GRB1
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Tissue Location Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)
Research Areas
Citations (0)

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Background

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

References

Skolnik E.Y.,et al.Cell 65:83-90(1991).
Antonetti D.A.,et al.Mol. Cell. Biol. 16:2195-2203(1996).
Udelhoven M.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15722
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