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HMOX1 / HO-1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - HMOX1 / HO-1 Antibody ALS15723
    Anti-HMOX1 / HO-1 antibody IHC staining of human spleen, macrophages.
  • WB - HMOX1 / HO-1 Antibody ALS15723
    HO-1, Human cell line mix.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P09601
Reactivity Human, Mouse, Rat, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Dilution IHC-P (5 µg/ml), WB (1:1000),
Additional Information
Gene ID 3162
Other Names Heme oxygenase 1, HO-1, 1.14.99.3, HMOX1, HO, HO1
Target/Specificity Detect an ~32kD protein, corresponding to the molecular mass of HO-1 on SDS Page Western Blots.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHMOX1 / HO-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMOX1
Synonyms HO, HO1
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Cellular Location Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)
Volume 50 µl
Research Areas
Citations (0)

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Background

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

References

Yoshida T.,et al.Eur. J. Biochem. 171:457-461(1988).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Keyse S.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:99-103(1989).
Shibahara S.,et al.Eur. J. Biochem. 179:557-563(1989).

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$ 395.00
Cat# ALS15723
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