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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UBE2D1 / UBCH5 Antibody (clone 2C6)   

UBE2D1 / UBCH5 Antibody (clone 2C6)

Mouse Monoclonal Antibody

     
  • IHC - UBE2D1 / UBCH5 Antibody (clone 2C6) ALS15740
    Anti-UBE2D1 / UBCH5 antibody IHC staining of human breast, epithelium.
  • WB - UBE2D1 / UBCH5 Antibody (clone 2C6) ALS15740
    Western blot of UBE2D1 expression in transfected 293T cell line by UBE2D1 monoclonal antibody...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P51668
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C6
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7321
Other Names Ubiquitin-conjugating enzyme E2 D1, 6.3.2.19, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Target/Specificity Human UBE2D1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsUBE2D1 / UBCH5 Antibody (clone 2C6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2D1
Synonyms SFT, UBC5A, UBCH5, UBCH5A
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis
Research Areas
Citations (0)

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Background

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

References

Scheffner M.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:8797-8801(1994).
Gehrke S.G.,et al.Blood 101:3288-3293(2003).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).

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$ 450.00
Cat# ALS15740
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