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HEXIM1 Antibody (aa181-230)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | O94992 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 10614 |
|---|---|
| Other Names | Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1 |
| Target/Specificity | HEXIM1 Antibody detects endogenous levels of total HEXIM1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | HEXIM1 Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HEXIM1 |
|---|---|
| Synonyms | CLP1, EDG1, HIS1, MAQ1 |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
| Cellular Location | Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050) |
| Tissue Location | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
References
Kusuhara M.,et al.Biomed. Res. 20:273-279(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wittmann B.M.,et al.Cancer Res. 63:5151-5158(2003).
Ouchida R.,et al.Genes Cells 8:95-107(2003).
Yik J.H.N.,et al.Mol. Cell 12:971-982(2003).
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