|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1|
|Target/Specificity||HEXIM1 Antibody detects endogenous levels of total HEXIM1 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||HEXIM1 Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, EDG1, HIS1, MAQ1|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.|
|Cellular Location||Nucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclear|
|Tissue Location||Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Kusuhara M.,et al.Biomed. Res. 20:273-279(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wittmann B.M.,et al.Cancer Res. 63:5151-5158(2003).
Ouchida R.,et al.Genes Cells 8:95-107(2003).
Yik J.H.N.,et al.Mol. Cell 12:971-982(2003).
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