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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EFNA1 / Ephrin A1 Antibody (aa66-115)   

EFNA1 / Ephrin A1 Antibody (aa66-115)

Rabbit Polyclonal Antibody

     
  • IHC - EFNA1 / Ephrin A1 Antibody (aa66-115) ALS15756
    Human, Brain, Cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE)
  • IF - EFNA1 / Ephrin A1 Antibody (aa66-115) ALS15756
    Immunofluorescence of HeLa cells, using EFNA1 Antibody.
  • WB - EFNA1 / Ephrin A1 Antibody (aa66-115) ALS15756
    Western blot of extracts from 293/Jurkat cells, using EFNA1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P20827
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 1942
Other Names Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, TNF alpha-induced protein 4, Ephrin-A1, secreted form, EFNA1, EPLG1, LERK1, TNFAIP4
Target/Specificity EFNA1 Antibody detects endogenous levels of total EFNA1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsEFNA1 / Ephrin A1 Antibody (aa66-115) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFNA1
Synonyms EPLG1, LERK1, TNFAIP4
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Tissue Location Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

References

Holzman L.B.,et al.Mol. Cell. Biol. 10:5830-5838(1990).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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$ 395.00
Cat# ALS15756
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