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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50)   

BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • IHC - BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50) ALS15763
    Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE)
  • WB - BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50) ALS15763
    Western blot of extracts from RAW264.7 cells, using BHLHB3 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9C0J9
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution ELISA (1:40000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 79365
Other Names Class E basic helix-loop-helix protein 41, bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, hDEC2, Enhancer-of-split and hairy-related protein 1, SHARP-1, BHLHE41, BHLHB3, DEC2, SHARP1
Target/Specificity BHLHB3 Antibody detects endogenous levels of total BHLHB3 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsBHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BHLHE41
Synonyms BHLHB3, DEC2, SHARP1
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}
Tissue Location Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney
Volume 50 µl
Research Areas
Citations (0)

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Background

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

References

Fujimoto K.,et al.Biochem. Biophys. Res. Commun. 280:164-171(2001).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Garriga-Canut M.,et al.J. Biol. Chem. 276:14821-14828(2001).
Kawamoto T.,et al.Biochem. Biophys. Res. Commun. 313:117-124(2004).
Li Y.,et al.Biochem. J. 382:895-904(2004).

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$ 395.00
Cat# ALS15763
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