|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Protein kinase C-binding protein 1, Cutaneous T-cell lymphoma-associated antigen se14-3, CTCL-associated antigen se14-3, Rack7, Zinc finger MYND domain-containing protein 8, ZMYND8, KIAA1125, PRKCBP1, RACK7|
|Target/Specificity||PKCB1 Antibody detects endogenous levels of total PKCB1 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||ZMYND8 / RACK7 Antibody (aa581-630) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1125, PRKCBP1, RACK7|
|Function||May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.|
|Tissue Location||Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL)|
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Provided below are standard protocols that you may find useful for product applications.
Fossey S.C.,et al.Mamm. Genome 11:919-925(2000).
Eichmueller S.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
Mikhailik A.,et al.Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Grkovic S.,et al.Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Hirosawa M.,et al.DNA Res. 6:329-336(1999).
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