|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Protein SSXT, Protein SYT, Synovial sarcoma translocated to X chromosome protein, SS18, SSXT, SYT|
|Target/Specificity||SYT (A7) pAb detects endogenous levels of SYT protein.|
|Reconstitution & Storage||Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||SS18 Antibody (Ala7) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.|
|Tissue Location||Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas|
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Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
Clark J.,et al.Nat. Genet. 7:502-508(1994).
Brodin B.,et al.Gene 268:173-182(2001).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Fligman I.,et al.Am. J. Pathol. 147:1592-1599(1995).
de Bruijn D.R.,et al.Oncogene 20:3281-3289(2001).
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