|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Dolichol-phosphate mannosyltransferase subunit 1, 188.8.131.52, Dolichol-phosphate mannose synthase subunit 1, DPM synthase subunit 1, Dolichyl-phosphate beta-D-mannosyltransferase subunit 1, Mannose-P-dolichol synthase subunit 1, MPD synthase subunit 1, DPM1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DPM1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.|
|Cellular Location||Endoplasmic reticulum.|
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Provided below are standard protocols that you may find useful for product applications.
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.
Tomita S.,et al.J. Biol. Chem. 273:9249-9254(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Colussi P.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7873-7878(1997).
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