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NKX2-5 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - NKX2-5 Antibody (Internal) ALS15782
    Anti-NKX2-5 antibody IHC staining of human heart.
  • WB - NKX2-5 Antibody (Internal) ALS15782
    NKX2-5 antibody (0.3 ug/ml) staining of Human Heart lysate (35 ug protein/ml in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P52952
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 35kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 1482
Other Names Homeobox protein Nkx-2.5, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, NKX2-5, CSX, NKX2.5, NKX2E
Target/Specificity Human NKX2-5. This antibody is expected to recognize all three reported isoforms (NP_004378.1; NP_001159647.1; NP_001159648.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsNKX2-5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX2-5
Synonyms CSX, NKX2.5, NKX2E
Function Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.
Cellular Location Nucleus.
Tissue Location Expressed only in the heart.
Research Areas
Citations (0)

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Background

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.

References

Turbay D.,et al.Mol. Med. 2:86-96(1996).
Tate G.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15782
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