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TIAL1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q01085 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 7073 |
|---|---|
| Other Names | Nucleolysin TIAR, TIA-1-related protein, TIAL1 |
| Target/Specificity | Human TIAL1. This antibody is expected to recognize both isoforms (NP_003243.1; NP_001029097.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | TIAL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIAL1 |
|---|---|
| Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule. Cytoplasm, Stress granule Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity) Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902} |
| Tissue Location | Expressed in brain, heart, kidney, lung and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
References
Kawakami A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8681-8685(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Choudhary C.,et al.Science 325:834-840(2009).
Reinhardt H.C.,et al.Mol. Cell 40:34-49(2010).
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