|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog|
|Dilution||ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||Nucleolysin TIAR, TIA-1-related protein, TIAL1|
|Target/Specificity||Human TIAL1. This antibody is expected to recognize both isoforms (NP_003243.1; NP_001029097.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TIAL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Kawakami A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8681-8685(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Choudhary C.,et al.Science 325:834-840(2009).
Reinhardt H.C.,et al.Mol. Cell 40:34-49(2010).
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