|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0-0.01 µg/ml)|
|Other Names||Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TPPP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Seki N.,et al.J. Hum. Genet. 44:121-122(1999).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Lindersson E.,et al.J. Biol. Chem. 280:5703-5715(2005).
Vincze O.,et al.Biochemistry 45:13818-13826(2006).
Olah J.,et al.FEBS Lett. 580:5807-5814(2006).
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