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ETFB Antibody (aa152-165)

Goat Polyclonal Antibody

     
  • IHC - ETFB Antibody (aa152-165) ALS15789
    Anti-ETFB antibody IHC staining of human liver.
    detail
  • WB - ETFB Antibody (aa152-165) ALS15789
    ETFB antibody (0.1 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P38117
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 28kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 2109
Other Names Electron transfer flavoprotein subunit beta, Beta-ETF, ETFB
Target/Specificity Human ETFB. This antibody is expected to recognize both reported isoforms (NP_001976.1; NP_001014763.1). Amino acid numbering in the name above refers to NP_001976.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsETFB Antibody (aa152-165) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ETFB (HGNC:3482)
Function Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918).
Cellular Location Mitochondrion matrix
Tissue Location Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
Research Areas
Citations (0)
citation

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Background

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

References

Finocchiaro G.,et al.Eur. J. Biochem. 213:1003-1008(1993).
Olsen R.K.J.,et al.Hum. Mutat. 22:12-23(2003).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS15789
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