ETFB Antibody (aa152-165)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P38117 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 28kDa |
Dilution | ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Gene ID | 2109 |
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Other Names | Electron transfer flavoprotein subunit beta, Beta-ETF, ETFB |
Target/Specificity | Human ETFB. This antibody is expected to recognize both reported isoforms (NP_001976.1; NP_001014763.1). Amino acid numbering in the name above refers to NP_001976.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | ETFB Antibody (aa152-165) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ETFB (HGNC:3482) |
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Function | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918). |
Cellular Location | Mitochondrion matrix |
Tissue Location | Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
References
Finocchiaro G.,et al.Eur. J. Biochem. 213:1003-1008(1993).
Olsen R.K.J.,et al.Hum. Mutat. 22:12-23(2003).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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