|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Dog|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Plakophilin-2, PKP2|
|Target/Specificity||Human PKP2 / Plakophilin 2. This antibody is expected to recognize both reported isoforms (NP_001005242.2; NP_004563.2).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||PKP2 / Plakophilin 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in junctional plaques.
Mertens C.,et al.J. Cell Biol. 135:1009-1025(1996).
Rampazzo A.,et al.Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mertens C.,et al.Differentiation 64:277-290(1999).
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