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CYP21A2 Antibody (aa151-200)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P08686 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Dilution | ELISA (1:20000), IHC-P (20 µg/ml), WB (1:500-1:1000) |
| Gene ID | 1589 |
|---|---|
| Other Names | Steroid 21-hydroxylase, 1.14.99.10, 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21, Cytochrome P450-C21B, CYP21A2, CYP21, CYP21B |
| Target/Specificity | Cytochrome P450 21A2 Antibody detects endogenous levels of total Cytochrome P450 21A2 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | CYP21A2 Antibody (aa151-200) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP21A2 |
|---|---|
| Synonyms | CYP21, CYP21B |
| Function | A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11- deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
References
Higashi Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2841-2845(1986).
White P.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5111-5115(1986).
Rodrigues N.R.,et al.EMBO J. 6:1653-1661(1987).
Globerman H.,et al.J. Clin. Invest. 82:139-144(1988).
Helmberg A.,et al.Mol. Endocrinol. 6:1318-1322(1992).
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