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>   home   >   Products   >   Primary Antibodies   >   MSH3 Antibody (aa51-100)   

MSH3 Antibody (aa51-100)

Rabbit Polyclonal Antibody

     
  • IHC - MSH3 Antibody (aa51-100) ALS15800
    Anti-MRP1 / MSH3 antibody IHC staining of human skeletal muscle.
  • WB - MSH3 Antibody (aa51-100) ALS15800
    Western blot of extracts from HUVEC cells, using MSH3 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P20585
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 127kDa
Dilution ELISA (1:20000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 4437
Other Names DNA mismatch repair protein Msh3, hMSH3, Divergent upstream protein, DUP, Mismatch repair protein 1, MRP1, MSH3, DUC1, DUG
Target/Specificity MSH3 Antibody detects endogenous levels of total MSH3 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsMSH3 Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSH3
Synonyms DUC1, DUG
Function Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Volume 50 µl
Citations (0)

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Background

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

References

Fujii H.,et al.J. Biol. Chem. 264:10057-10064(1989).
Acharya S.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:13629-13634(1996).
Shimada T.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Schmutte C.,et al.J. Biol. Chem. 276:33011-33018(2001).

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$ 395.00
Cat# ALS15800
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