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MSH3 Antibody (aa51-100)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P20585 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 127kDa |
| Dilution | ELISA (1:20000), IHC-P (20 µg/ml), WB (1:500-1:1000) |
| Gene ID | 4437 |
|---|---|
| Other Names | DNA mismatch repair protein Msh3, hMSH3, Divergent upstream protein, DUP, Mismatch repair protein 1, MRP1, MSH3, DUC1, DUG |
| Target/Specificity | MSH3 Antibody detects endogenous levels of total MSH3 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | MSH3 Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MSH3 |
|---|---|
| Synonyms | DUC1, DUG |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
References
Fujii H.,et al.J. Biol. Chem. 264:10057-10064(1989).
Acharya S.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:13629-13634(1996).
Shimada T.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Schmutte C.,et al.J. Biol. Chem. 276:33011-33018(2001).
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