|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:5000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Carboxypeptidase E, CPE, 188.8.131.52, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE|
|Target/Specificity||CPE Antibody detects endogenous levels of total CPE protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||Carboxypeptidase E / CPE Antibody (aa271-320) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.|
|Cellular Location||Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.|
|Tissue Location||Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Manser E.,et al.Biochem. J. 267:517-525(1990).
Utsunomiya N.,et al.Diabetologia 41:701-705(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lee T.K.,et al.J. Clin. Invest. 121:880-892(2011).
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