|Application ||WB, IHC-P, IF, IP|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1, LCP1, PLS2|
|Reconstitution & Storage||Stable for 24 months when stored at 2-8°C.|
|Precautions||LCP1 / L-Plastin Antibody (clone LPL4A.1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation.|
|Tissue Location||Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.|
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Provided below are standard protocols that you may find useful for product applications.
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Zu Y.,et al.Biochemistry 29:8319-8324(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Lin C.-S.,et al.Mol. Cell. Biol. 8:4659-4668(1988).
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