|Application ||WB, IHC-P, E|
|Clone Names||X75 (3C8/4)|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Mucin-16, MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125, MUC16, CA125|
|Target/Specificity||Specific for Mucin 16, also known as Ovarian Cancer Antigen CA-125. Recognizes epitope specificity group B (ISOBM classification) similar to M-11. Mucin 16 is a serum marker, overexpressed in epithelial ovarian cancer cells and is routinely used for ...|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MUC16 / CA125 Antibody (clone X75 (3C8/4)) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain|
|Tissue Location||Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas|
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Provided below are standard protocols that you may find useful for product applications.
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
O'Brien T.J.,et al.Tumor Biol. 23:154-169(2002).
O'Brien T.J.,et al.Tumor Biol. 22:348-366(2001).
Yin B.W.T.,et al.J. Biol. Chem. 276:27371-27375(2001).
Lloyd K.O.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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