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NRBP1 / NRBP Antibody (clone 2C8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP, FC |
|---|---|
| Primary Accession | Q9UHY1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2C8 |
| Calculated MW | 60kDa |
| Dilution | Flo (1:100), IHC-P (10 µg/ml), WB (1:500) |
| Gene ID | 29959 |
|---|---|
| Other Names | Nuclear receptor-binding protein, NRBP1, BCON3 {ECO:0000312|EMBL:AAF21967.1}, NRBP |
| Target/Specificity | Human NRBP1 / MADM |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | NRBP1 / NRBP Antibody (clone 2C8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRBP1 |
|---|---|
| Synonyms | BCON3 {ECO:0000312|EMBL:AAF21967.1}, NRB |
| Function | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). |
| Cellular Location | Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia |
| Tissue Location | Ubiquitously expressed in all tissues examined with high levels in the testis. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
References
Hooper J.D.,et al.Genomics 66:113-118(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
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